Keratotic plug remover

ABSTRACT

A keratotic plug remover composition comprising a polymer compound having a salt forming group is disclosed. The composition according to the invention can effectively remove keratotic plugs in the skin pores, so that the conspicuousness of the skin pores is mitigated and clean and healthy skin pores can be maintained. The composition does not hurt the skin.

This application is a Continuation of application Ser. No. 07/882,979,filed on May 14, 1992, now abandoned.

BACKGROUND OF THE INVENTION

1. Field of the Invention

The present invention relates to a keratotic plug remover whichexcellently removes keratotic plugs formed in the pores of the skin, anda method of removing keratotic plugs from the skin utilizing such akeratotic plug remover.

2. Discussion of the Background

Having conspicuous pores in the skin is a serious skin problem,especially for women, and is mainly caused by keratotic plugs formed inthe pores of the skin. Keratotic plugs are dead epidermal cellskeratinized together with sebaceous matters and dirt which plug thepores of the skin. If proper treatment is not given, not onlyconspicuous pores but also various skin troubles result. Accordingly,removal of keratotic plugs is advisable in view of the health and beautyof the skin.

Ordinary face detergents, make-up removers, however, cannot sufficientlyremove the keratotic plugs.

Pack preparations, which are applied to the skin and peeled off afterdried, and which generally contain a nonionic polymer such as polyvinylalcohol and polyvinyl pyrrolidone as a major component of a film formingagent, are still not sufficiently effective for removing dirt from theskin pores and especially for removing keratotic plugs.

Thus, there remains a need for a keratotic plug remover which caneffectively remove keratotic plugs formed in the pores of the skin and amethod of removing keratotic plugs from the skin utilizing such plugremovers.

SUMMARY OF THE INVENTION

Accordingly, it is one object of the present invention to provide novelkeratotic plug removers which effectively remove keratotic plugs fromthe skin.

It is another object of the present invention to provide a method forremoving keratotic plugs from the skin which utilized such keratoticplug removers.

These and other objects which will become apparent during the followingdetailed description have been achieved by the inventors discovery thata keratotic plug remover which comprises a synthetic polymer having asalt forming group can effectively remove keratotic plugs and dirt fromthe pores of the skin.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS

The salt forming group of the polymer which is useful in the presentinvention is not particularly limited as long as it can form a salt inthe presence of an acid or a base, and anionic, cationic and amphotericgroups are suitable. Examples of the salt forming group are carboxyl,sulfonic acid group, sulfuric acid residual group (--OSO₃ H), phosphoricacid residual group (--OPO₃ H₂), nitric acid residual group (--NO₂),amino group, ammonium group, and the like. Two or more of these groupsmay be present in one compound.

The polymer compound which is useful in the present invention ispreferably water-soluble from the viewpoint of good appearance, but itis not necessarily water-soluble for the purpose of achieving theeffects of this invention. The compounds which are not water-soluble maytake the form of dispersion and/or emulsion.

Examples of the polymers useful in the present invention include:hyaluronic acid, sodium hyaluronate, sodium chondroitin sulfate whichare mucopolysaccharides; alginic acid, sodium alginate, ammoniumalginate, sodium carboxylmethylcellulose, and carboxymethyl amylosewhich are hemicelluloses. These are of natural origin or semisynthesizedpolymers. In this invention, synthesized polymers are more preferable.Examples of the synthesized polymers include (A) polymers of one or moremonomers listed in (1) to (3) below, (B) copolymers of the monomers aslisted in (1) to (3) and another monomer which has no salt forminggroup, such as vinyl esters of aliphatic carboxylic acid such as vinylacetate, (meth)acrylic esters such as methyl methacrylate, alkyl vinylethers such as methyl vinyl ether, N-vinyl cyclic amides such asN-vinylpyrrolidone, styrene and alkyl-substituted styrene, and (C)mixtures of the above-mentioned polymers.

(1) Anionic monomers:

Acrylic acid (AA), Methacrylic acid (MA), Maleic acid, itaconic acid andthe like, which are unsaturated carboxylic acid monomers or theiranhydrides or their salts;

Styrene sulfonic acid, 2-Acrylamide-2-methyl propane sulfonic acid(AMPS) and the like, which are unsaturated sulfonic acid monomers ortheir salts;

Vinyl phosphonic acid, Acid phosphoxyethyl (meth)acrylate and the like,which are unsaturated phosphoric monomers.

(2) Cationic monomers

Dimethylaminoethyl acrylate (DMAEA), Dimethylaminoethyl methacrylate(DMAEMA), Dimethylaminopropylacrylamide (DMAPAAm), Dimethylaminopropylmethacrylamide (DMAPMAAm), and the like, which are (meth)acrylamides or(meth)acrylic acid esters having a dialkylamino group;

Dimethylaminostyrene (DMASt), Dimethyaminomethylstyrene (DMAMSt) and thelike, which are styrenes having a dialkylamino group;

4-Vinyl pyridine, 2-vinyl pyridine and the like, which are vinylpyridines;

Quaternarized products of these with a known quatenarizing agent such asalkyl halide, benzyl halide, alkyl or aryl sulfonic acid, or dialkylsulfate.

(3) Amphoteric monomers

N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammonium betaine,N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammonium betaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N, N-dimethylammoniumbetaine, N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine.

When the salt forming group of these polymers is not ionized, it ispreferred to ionize it via neutralization with known acids such ashydrochloric acid and sulfuric acid which are inorganic acids; aceticacid, propionic acid, lactic acid, succinic acid, glycol acid which areorganic acids, or with known bases such as triethylamine, trimethylaminewhich are tertiary amines; ammonia; or sodium hydroxide.

Among the mentioned polymer compounds, preferred ones in view of themildness to the skin and high effectiveness for removing keratotic plugsare polymers of one or more cationic monomers, copolymers between one ofthese polymers and an amphoteric monomer or a monomer having no saltforming groups, and mixtures of these polymers.

Preferable examples of the cationic monomers includedimethylaminoethylacrylate (DMAEA), dimethylaminoethylmethacrylate(DMAEMA), dimethylaminopropylacrylamine (DMAPAAm), dimethylaminopropylmethacrylamide (DMAPMAAm) and the like, which are (meth)acrylic estersor (meth)acrylamides having a dialkylamino group; and quaternarycompound of them which are quaternarized with a known quaternarizingagent such as alkyl halide, benzyl halide, alkyl or aryl sulfonic acidor dialkyl sulfate. Among them, especially preferred aredimethylaminoethylmethacrylate (DMAEMA) and its quaternarized products;quaternarized products of dimethylaminopropyl methacrylamide (DMAPMAAm);polymers of one or more of these monomers; copolymers between one ormore of these monomers and the above-mentioned monomers; and mixturesthereof.

The molecular weight (weight average) of these polymers is preferably inthe range of from 10,000 to 1,500,000, and especially from 100,000 to1,000,000. Molecular weights less than 10,000 will result ininsufficient film strength and easily breakable films upon peeling-off.Polymers having a molecular weight over 1,500,000 are difficult tomanufacture.

The preferable amount of the polymer to be incorporated into thekeratotic plug remover preparation according to the invention is from0.01 to 70% by weight, preferably 5 to 40% by weight based on the totalweight of the preparation.

The above-mentioned synthesized polymers are used as dissolved in asolvent. The solvent useful in this invention is volatile and is notparticularly limited as long as it can stably dissolve the polymers andis safe to the skin. Examples of such solvents include water, ethanol,isopropyl alcohol (IPA) and the like. They are used singly or incombination. The amount of the solvent is modified depending on theproperties of the polymer compounds, optional ingredients and forms ofthe preparation, and is generally from 30 to 99.99% by weight, andpreferably from 60 to 95% by weight, based on the total weight of thecomposition.

The efficacy of the keratotic plug remover of this invention is enhancedwhen a pigment is further incorporated together with the mentionedpolymers. The pigment is not particularly limited, and both organic andinorganic pigments can be used. Examples of the inorganic pigments arezinc oxide, titanium oxide, silica, alumina, barium sulfate, zirconiumoxide, calcium carbonate, calcium silicate, ceramics, hydroxyapatite,boron nitride, sericite, mica, talc, kaolin, montmorillonite, hectorite,saponite, black iron oxide, yellow iron oxide, red iron oxide, prussianblue, ultramarine, carbon black, pearlescent pigments and so on.Examples of the organic pigments are silk powders, cellulose powders,poly(meth)acrylic ester resins, polyamide resins, polyolefin resins,polyimide resins, polyurethane resins, polyester resins, polyetherresins, polyvinyl chloride resins, urea resins, polyformaldehyde resins,polycarbonate resins, polyvinylacetate resins, polyvinylidene chlorideresins, polyacrylonitrile resins, polysulfone resins, polystyreneresins, polyurea resins, silicone resins, melamine resins,polytetrafluoroethylene resins, rake pigments and azo dyes.

The particle size of the pigments is from 0.001 to 1000 micrometers, andpreferably from 0.01 to 500 micrometers. Particle size of less than0.001 micrometer is not preferred because good dispersibility cannot beobtained. Particle size over 1000 micrometers is not preferred, either,because of an unfavorable sensation to the skin. The mentioned pigmentscan be used as a complex or a mixture of one or more, if desired. Theamount of the pigment is from 0.1 to 70% by weight, preferably from 1 to40% by weight based on the total weight of the preparation.

When an oil component is further incorporated together with thepolymers, the keratotic plug remover of this invention can achieveexcellent removal of keratotic plugs without giving irritation to theskin. This is because the strength of the film at which it breaks uponpeeling-off can be controlled by the oil component.

The oil component which is useful in this invention is a glycerolderivative represented by formula (I): ##STR1## wherein one of Z¹ and Z²represents R² --Y-- and the other represents a hydroxyl group or R³--Y--, and R¹, R² and R³ independently represent a hydrocarbon group,the total carbon number of which ranges from 13 to 40, and thehydrocarbon group may or may not be substituted by a silicone residualgroup, X and Y independently represent an oxygen atom or a group--COO--, (a carboxyl group in which the C atom is bonded to R¹, R², orR³). Other oily ingredients which are generally incorporated intocosmetic preparations can also be used. Examples of the oil componentwhich is useful in this invention include vegetable oils such as avocadooil, tsubaki oil, macadamia nut oil, olive oil and jojoba oil; animaloils and fats such as beef tallow, lard and egg yolk fat; aliphaticacids such as oleic acid and isostearic acid; alcohols such as hexadecylalcohol and oleyl alcohol; esters such as cetyl 2-ethylhexanoate,2-ethylhexyl palmitate, 2-octyldodecyl myristate, neopentyl glycoldi-2-ethyl hexanoate, 2-octyldodecyl oleate, isopropyl myristate,glycerol triisostearate, mono-2-ethylhexanoic glyceryldi-paramethoxycinnamate; and hydrocarbons such as dimethylpolysiloxane,dimethyl cyclopolysiloxane, methylphenyl polysiloxane, methylhydrogenpolysiloxane, octamethyl cyclotetrasiloxane, octamethylcyclopentasiloxane, decamethylcyclopentasiloxane, liquid paraffin,squalane, vaseline and solid paraffin.

Among these oil components, glycerol derivatives of formula (1) whichare liquid at 20° C. are preferred, and particularly,tri-2-ethylhexanoic glycerol, 1-isostearoyl-3-myristoyl glycerol,2-ethylhexanoic diglyceride, 1-hexyl-3-undecamethylhexasiloxy propynylglycerol are most preferred.

The amount of the oil components to be incorporated into the keratoticplug remover of this invention is from 0.5 to 30% by weight, preferably,1 to 15% by weight based on the total weight of composition.

The keratotic plug remover preparation of this invention can furthercontain optional ingredients which are generally incorporated intocosmetic preparations. Examples of such optional ingredients includeethylene glycol, diethylene glycol, triethylene glycol and higherpolyethylene glycols; propylene glycol, dipropylene glycol and higherpolypropylene glycols, 1,3-butylene glycol, 1,4-butylene glycol andother butylene glycols; glycerol, diglycerol and higher polyglycerols;sugaralcohols such as sorbitol, mannitol, xylitol and maltitol; ethyleneoxides (hereinafter referred to as EO) such as glycerols; additionproducts of propylene oxide (hereinafter referred to as PO); EO or POadducts of sugaralcohols; monosaccharides such as galactose, glucose andfructose, and their EO or PO adducts; polysaccharides such as maltoseand lactose, and their EO or PO adducts (polyols); surfactants such asPOE alkyl ethers (POE is polyoxyethylene), POE branched alkyl ethers,POE sorbitan esters, POE glycerol fatty acid esters, POE hydrogenatedcastor oil, sorbitan ester, glycerol fatty acid esters and polyglycerolfatty acid ester; drugs such as vitamins, antiphlogistics, activators,UV absorbers and the like; water-swelling clay minerals such asmontmorillonite, saponite and hectorite; polysaccharides such ascarageenan, xanthangum, sodium alginate, pullulan, methylcellulose,carboxymethylcellulose, hydroxyethylcellulose andhydroxypropylcellulose; synthetic polymers such as carboxyvinylpolymers, polyvinyl pyrrolidones and polyvinyl alcohols. They areincorporated into the preparation of the present invention in suchamounts that will not impede the effects of the invention. Inparticular, when polyols are used, they are preferably incorporated by0.01 to 50% by weight based on the total preparation.

The keratotic plug remover according to this invention may take a formof a poultice using cotton cloth, rayon cloth, tetron cloth, nyloncloth, either woven or non-woven, or using a plastic film sheet, besidepack preparations.

The keratotic plug remover of this invention can be manufacturedaccording to conventional processes for the manufacture of ordinarypacks and poultice.

The manner of removing keratotic plugs by the use of the keratotic plugremover of the invention is the same as the manner of using ordinarypacks and poultice. Namely, when a pack preparation is used, it is firstapplied to the part of the skin which has keratotic plugs, particularlylikely to the nose, chin and forehead, and after dried, it is peeledoff.

Since the keratotic plug remover of this invention effectively removeskeratotic plugs, the conspicuousness of the skin pores is mitigated,skin pores are maintained clean, and healthy skin can be obtained.Further, the remover of this invention does not hurt the skin.

Other features of the invention will become apparent in the course ofthe following descriptions of exemplary embodiments which are given forillustration of the invention and are not intended to be limitingthereof.

EXAMPLES

Where not otherwise indicated all amounts in the examples are in termsof % by weight based on the total weight of the composition.

Example 1

Keratotic plug removers were prepared according to the pack preparationmethod mentioned below using the polymers listed in Table 1. A panelwashed their face and used the preparation on their faces at anapplication rate of 0.1 ml/cm². The conditions of use were a temperatureof 25° C., 50% humidity for 30 minutes. When 30 minutes had passed, thepack was peeled off. The ratio of removal of the keratotic plugs wascalculated according to the following equation for evaluation. ##EQU1##

The results are also shown in Table 1.

Evaluation:

A: over 20% removal ration of keratotic plugs

B: 5 to 20% removal ratio of keratotic plugs

C: less than 5% removal ratio of keratotic plugs

Preparation:

    ______________________________________    Polymer               15 to 20% by weight    Glycerol              5    HCO60 (polyoxyethylene hydrogenated                          1    castor oil 60EO adduct)    Ethanol               5    Perfume               0.5    Antiseptic            suitable amount    Purified water        67.5 to 72.5    Total                 100.0    ______________________________________

                                      TABLE 1    __________________________________________________________________________                                           Evaluation                                      Anionic/                                           (Removal of    Polymers                          Cationic                                           keratotic plugs)    __________________________________________________________________________    IONIC    Poly 2-acrylamide-2-methylpropane sulfonate (AMPS)                                      anionic                                           A    (MW: 500,000)    Polymethacroyloxymethyl succinate (MW: 200,000)                                      anionic                                           A    Polymer of Na.styrene sulfonic acid (NaSS) (MW: 100,000)                                      anionic                                           A    Polymer of methacrylic acid (MAA) (MW: 200,000)                                      anionic                                           A    Copolymer of NaSS/MAA (1:1) (MW: 400,000)                                      anionic                                           A    Polymethacroyloxyethyl trimethyl ammonium chloride (QDM)                                      cationic                                           A    (MW: 400,000)    Polymethacroyloxyethyl triethyl ammonium diethyl sulfate                                      cationic                                           A    (DEAMA-DES) (MW: 300,000)    Polymethacrylamidepropyl trimethyl ammonium    chloride (NAPTAC, MW: 300,000)/polyacrylamidepropyl    trimethyl ammonium chloride (DMAPAAm-Q, MW: 300,000) copolymer    (8:2 by molar ratio)              cationic                                           A    NONIONIC    Polyvinyl alcohol (PVA) (MW: 100,000)                                      --   C    Polyethylene oxide (PEO) (MW: 1,000,000)                                      --   C    Pullulan (MW: 70,000)             --   C    Hydroxyethylcellulose (HEC) (WW: 100,000)                                      --   C    Polyvinyl pyrrolidone (PVP) (MW: 600,000)                                      --   C    __________________________________________________________________________

Example 2

Keratotic plug removers were prepared using the polymers listed in Table2, and the removal ratio of keratotic plugs and the pain at the time ofpeeling-off were checked.

The polymers were individually prepared into an aqueous 20-30% by weightsolution, and members of the panel used in the same manner as in Example1.

Removal ratio of keratotic plugs:

See the equation in Example 1.

Evaluation:

(Removal ratio of keratotic plugs)

A: 35% or more

B: 20 to 34%

C: 5 to 19%

D: less than 5%

(Pain at the time of peeling-off)

slight pain: =

considerable pain:

                                      TABLE 2    __________________________________________________________________________                                  Anionic/                                       Removal of                                               Pain upon    Polymers                      Cationic                                       Keratotic plugs                                               peeling-off    __________________________________________________________________________    Poly-2-acrylamide-2-methylpropane sulfonate (AMPS)                                  Anionic                                       B       ++    (MW: 500,000)    Polymethacryloyloxy methyl succinate (MW: 200,000)                                  Anionic                                       B       +    Polymer of Na.styrene sulfonic acid (NaSS) (MW:                                  Anionic                                       A       ++    100,000)    Methacrylic acid (MAA) polymer (KW: 200,000)                                  Anionic                                       B       ++    NaSS/MAA copolymer (1:1) (HW: 400,000)                                  Anionic                                       A       ++    Polymethacryloyloxyethyl trimethylammonium chloride                                  Cationic                                       A       +    (QDM)    (MW: 400,000)    Polymethacrylamidepropyl trimethylammonium chloride                                  Cationic                                       A       +    (MAPTAC)    (MW: 300,000)    MAPTAC (MW: 300,000)/polyacrylamidepropyl trimethyl                                  Cationic                                       A       +    ammonium chloride (DMAPAAm-Q) (MW: 300,000) copolymer    (8:2)    MAPTAC (MW: 300,000)/QDM (MW: 400,000) mixture                                  Cationic                                       A       +    __________________________________________________________________________

Example 3

Keratotic plug removers having the formulations as in Table 3 wereprepared according to the conventional manner, and the keratotic plugremoving performance was evaluated. The results are shown in Table 4.

Evaluation method:

Panel members washed their faces and applied keratotic plug removersonto their cheeks (0.1 ml/cm²). The application was allowed to set at25° C., humidity 50% for 30 minutes, and subsequently the pack film waspeeled off. The number of the members who used an invention product A ontheir left cheek and an invention product B on their right cheek was thesame as the number of the members who used an invention product B ontheir left cheek and an invention product A on their right cheek.

The panel members evaluated the removers by answering "Invention productA removed better", "Invention product A and Invention product B werealmost the same concerning the removal performance" or "Inventionproduct B removed better", and their percentages were obtained.

                  TABLE 3    ______________________________________                             Invention                    Invention  products                    products A B    Components (% by weight)                      1      2      3    1    2    ______________________________________    Poly-2-acrylamide-2-methyl-                      25     25     --   25   --    propane sulfonate (AMPS)    (MW: 500,000)    Polymethacroyloxyethyltrimethyl                      --     --     25   --   25    ammonium chloride (QDM)    (MW: 400,000)    Silica (av. particle size = 5                      --     --     10   --   --    micrometers    Zinc oxide (av. particle size: 0.04                      3      --     --   --   --    micrometers)    Sericite (long axis: 5 to 10                      --     10     --   --   --    micrometers)    HCO40 (Polyoxyethylene                      3      3      3    3    3    hydrogenated castor oil    60 EO adduct)    Glycerol          5      5      5    Perfume           0.5    0.5    0.5  0.5  0.5    Antiseptic        suitable amount    Purified water    balance    ______________________________________

                                      TABLE 4    __________________________________________________________________________                    Invention product A                              Invention products                                        Invention product    Left (Right)           Right (Left)             removed better                    A and B are similar                              B removed better    __________________________________________________________________________    Invention             Invention                    90        10        0             product A1       product B1             Invention                    Invention 90        10 0             product A2       product B2             Invention                    Invention 80        20 0             product A3       product B2    __________________________________________________________________________

Example 4

The keratotic plug removers as formulated in Table 5 were preparedaccording to the conventional manner.

The obtained keratotic plug removers were used by a panel consisting of20 members as in the same manner described in Example 1. The pain uponpeeling-off was evaluated with the criteria below. The results are shownin Table 5. Concerning the keratotic plug removal, all preparationsremoved well.

Evaluation:

O: No pain felt

X: Pain felt

                                      TABLE 5    __________________________________________________________________________                              Invention                                       Invention                              products C                                       products D    Components (% by weight)  1  2  3  1  2    __________________________________________________________________________    Poly-2-acrylamide-2-methylpropans sulfonate (AMPS)                              25 25 -- 25 --    (MW: 500,000)    Polymethacroyloxy ethyl triammonium chloride                              -- -- 25 -- 25    (QDM) (MW: 400,000)    Tri-2-ethyl hexanoic glycerol                              3  -- 3  -- --    2-Ethylhexanoic diglyceride                              -- 3  -- -- --    Glycerol                  5  5  5  5  5    HCO40 (Polyoxyethylene hydrogenated castor oil                              1  1  1  1  1    60 EO adduct)    Squalane                  1  1  1  -- --    Ethanol                   5  5  5  5  5    Perfume                   0.5                                 0.5                                    0.5                                       0.5                                          0.5    Antiseptic                suitable amount    Purified water            balance    Pain when peeled off      ◯                                 ◯                                    ◯                                       X  X    __________________________________________________________________________

Example 5

The keratotic plug removers as formulated in Table 6 were preparedaccording to the conventional manner.

The obtained keratotic plug removers removed keratotic plugs effectivelywithout giving pains at the time of peeling off.

                                      TABLE 6    __________________________________________________________________________                           Invention products C    Components (% by weight)                           4  5  6  7  8  9  10 11 12 13    __________________________________________________________________________    Polymethacrylamidepropyl trimethylammonium     10 10    chloride (MAPTAC) (MW: 500,000)    Polymethacryloyloxy ethyl trimethylammonium                                             10 10    chloride (QDM) (MW: 400,000)    Na.Styrene sulfonic acid/Methacrylic acid                           25    copolymer (MW: 400,000)    Poly 2-acrylamide-2-methylpropane sulfonate                              30          20    (AMPS) (MW: 500,000)    Polymethacrylamide propyl trimethylammonium                                 35             20    20    chloride (MAPTAC) (MW: 50,000)    Polymethacryloyloxy ethyl trimethylammonium                                    30 20    20    20    chloride (QDM) (MW: 70,000)    Polyvinyl alcohol (MW: 30,000)     5  5    PEG 200 (polyethylene glycol 200)                           5  5  5  5  3  3  3  3  3  3    HCO 40 (Polyoxyethylene hydrogenated castor                           1  1  1  1  1  1  1  1  1  1    oil 40 ED adduct)    Squalane               1  1  1  1  1  1  1  1  1  1    2-ethylhexanoic diglyceride                           3           2     3  3  3  3    Tri-2-ethylhexanoic glycerol                           1  2    1-Hexyl-3-undecamethylhexasiloxane                                    3     2     2     2    propynyl glycerol    1-isostearoyl-3-myristoylglycerol                              2  3           3     3    Silica                          10    Sericite                     10    Perfume                0.5                              0.5                                 0.5                                    0.5                                       0.5                                          0.5                                             0.5                                                0.5                                                   0.5                                                      0.5    Antiseptic             suitable amount    Water                  balance    __________________________________________________________________________

Example 6

A keratotic plug remover having the following formulation was prepared.

    ______________________________________    Polymethacryloyloxy trimethyl ammonium                           27.0 wt. %    chloride (QDM) (MW: 400,000)    Sorbitol               3.0    Sericite               3.0    Ethanol                5.0    Antiseptic             suitable amount    Water                  balance    ______________________________________

Example 7

A keratotic plug remover having the following formulation was prepared.

    ______________________________________    Polymethacryloyloxy trimethyl ammonium                           27.0 wt. %    chloride (QDM) (MW: 250,000)    Polyoxyethylene hydrogenated castor                           2.0    oil (E.O. 20)    Squalane               0.5    1-Isostearoyl-3-myristoyl glycerol                           1.5    (DGMI)    86% Glycerol           2.0    Propylene glycol       1.0    Sericite               3.0    Ethanol                5.0    Antiseptic             suitable amount    Water                  balance    ______________________________________

Example 8

A keratotic plug remover having the following formulation was prepared.

    ______________________________________    Polymethacryloyloxy trimethyl ammonium                             15.0 wt. %    chloride (QDM) (MW: 200,000)    Polymethacrylamidepropyl trimethyl ammonium                             15.0    chloride (MAPTAC) (MW: 300,000)    Polyoxyethylene hydrogenated castor oil                             1.5    (E.O. 40)    Squalane                 0.5    2-Ethylhexanoic triglyceride                             2.0    Sorbitol                 3.0    Kaolin                   7.0    Titanium oxide           2.0    Ethanol                  5.0    Antiseptic               suitable amount    Water                    balance    ______________________________________

What is claimed is:
 1. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition onto the skin,and peeling off the composition after the composition is dried, whereinsaid keratotic plug remover composition comprises a cationic polymercompound having a salt forming group, wherein said polymer is one memberselected from the group consisting of:(a) a polymer consisting of acationic monomer selected from the group consisting of quaternerizedproducts of each of dimethylaminoethyl acrylate, dimethylaminoethylmethacrylate, dimethylaminopropyl acrylamide, dimethylaminopropylmethacrylamide, dimethylaminostyrene, dimethylaminomethylstyrene,4-vinyl pyridine, 2-vinyl pyridine, and mixtures thereof; (b) acopolymer consisting of (1) a cationic monomer selected from the groupconsisting of quaternerized products of each of dimethylaminoethylacrylate, dimethylaminoethyl methacrylate, dimethylaminopropylacrylamide, dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine, N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 2. The method of claim 1, wherein said polymercompound having a salt forming group has a molecular weight of from10,000 to 1,500,000.
 3. The method of claim 1, wherein said polymercompound having a salt forming group is 0.01 to 70% by weight based onthe total weight of said composition.
 4. The method of claim 1, whereinsaid cationic polymer is a polymer of a cationic monomer selected fromthe group consisting of polymethacryloyloxyethyl trimethylammoniumchloride; polymethacrylamidepropyl trimethylammonium chloride;copolymers of methacrylamidepropyl trimethylammonium chloride andacrylamidepropyl trimethylammonium chloride; and copolymers ofmethacrylamidepropyl trimethylammonium chloride and methacryloyloxyethyltrimethylammonium chloride.
 5. The method of claim 1, wherein saidcationic polymer is said polymer (a).
 6. A method for removing keratoticplugs which comprises applying a keratotic plug remover composition ontothe skin, and peeling off the composition after the composition isdried, wherein said composition comprises a polymer having a saltforming group and a solvent, wherein said polymer is one member selectedfrom the group consisting of:(a) a polymer consisting of a cationicmonomer selected from the group consisting of quaternerized products ofeach of dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof; (b) a copolymer consisting of(1) a cationic monomer selected from the group consisting ofquaternerized products of each of dimethylaminoethyl acrylate,dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine, N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 7. The method of claim 6, wherein the amount of saidpolymer compound having a salt forming group is 0.01 to 70% by weight,and the amount of said solvent is 30 to 99.9% by weight based on thetotal weight of said composition.
 8. The method of claim 6, wherein saidcationic polymer is a polymer of a cationic monomer selected from thegroup consisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 9. The method of claim 6, wherein said cationic polymer issaid polymer (a).
 10. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition into the skin,and peeling off the composition after the composition is dried, whereinsaid composition comprises a polymer compound having a salt forminggroup and a pigment,wherein said polymer is one member selected from thegroup consisting of: (a) a polymer consisting of a cationic monomerselected from the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof; (b) a copolymer consisting of(1) a cationic monomer selected from the group consisting ofquaternerized products of each of dimethylaminoethyl acrylate,dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine,N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 11. The method of claim 10, wherein said polymercompound having a salt forming group is 0.01 to 70% by weight, and theamount of said pigment is 0.1 to 70% by weight based on the total weightof said composition.
 12. The method of claim 10, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 13. The method of claim 10, wherein said cationic polymer ispolymer (a).
 14. A method for removing keratotic plugs which comprisesapplying a keratotic plug remover composition onto the skin, and peelingoff the composition after the composition is dried, wherein saidcomposition comprises a polymer compound having a salt forming group, apigment and a solvent,wherein said polymer is one member selected fromthe group consisting of: (a) a polymer consisting of a cationic monomerselected from the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof; (b) a copolymer consisting of(1) a cationic monomer selected from the group consisting ofquaternerized products of each of dimethylaminoethyl acrylate,dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine, N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 15. The method of claim 14, wherein the amount of saidpolymer compound having a salt forming group is 0.01 to 70% by weight,the amount of said pigment is 0.1 to 70% by weight and the amount ofsaid solvent is 29.99 to 99.89% by weight based on the total weight ofsaid composition.
 16. The method of claim 14, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 17. The method of claim 14, wherein said cationic polymer issaid polymer (a).
 18. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition onto the skin,and peeling off the composition after the composition is dried, whereinsaid composition comprises a polymer compound having a salt forminggroup and an oil component,wherein said polymer is one member selectedfrom the group consisting of: (a) a polymer consisting of a cationicmonomer selected from the group consisting of quaternerized products ofeach of dimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof; (b) a copolymer consisting of(1) a cationic monomer selected from the group consisting ofquaternerized products of each of dimethylaminoethyl acrylate,dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine,N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 19. The method of claim 18, wherein said polymerhaving a salt forming group is 0.01 to 70% by weight and the amount ofsaid oil component is 0.5 to 30% by weight, based on the total weight ofsaid composition.
 20. The method of claim 18, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 21. The method of claim 18, wherein said cationic polymer issaid polymer (a).
 22. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition onto the skin,and peeling off the composition after the composition is dried, whereinsaid composition comprises a polymer compound having a salt forminggroup, an oil component and a solvent,wherein said polymer is one memberselected from the group consisting of: (a) a polymer consisting of acationic monomer selected from the group consisting of quaternerizedproducts of each of dimethylaminoethyl acrylate, dimethylaminoethylmethacrylate, dimethylaminopropyl acrylamide, dimethylaminopropylmethacrylamide, dimethylaminostyrene, dimethylaminomethylstyrene,4-vinyl pyridine, 2-vinyl pyridine, and mixtures thereof, (b) acopolymer consisting of (1) a cationic monomer selected from the groupconsisting of quaternerized products of each of dimethylaminoethylacrylate, dimethylaminoethyl methacrylate, dimethylaminopropylacrylamide, dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting ofN-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine,N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammonium betaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 23. The method of claim 22, wherein the amount of saidpolymer compound having a salt forming group is 0.01 to 70% by weight,the amount of said oil component is 0.5 to 30% by weight and the amountof said solvent is 29.99 to 99.49% by weight based on the total weightof said composition.
 24. The method of claim 22, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 25. The method of claim 22, wherein said cationic polymer issaid polymer (a).
 26. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition onto the skin,and peeling off the composition after the composition is dried, whereinsaid composition comprises a polymer compound having a salt forminggroup, a pigment and an oil component,wherein said polymer is one memberselected from the group consisting of: (a) a polymer consisting of acationic monomer selected from the group consisting of quaternerizedproducts of each of dimethylaminoethyl acrylate, dimethylaminoethylmethacrylate, dimethylaminopropyl acrylamide, dimethylaminopropylmethacrylamide, dimethylaminostyrene, dimethylaminomethylstyrene,4-vinyl pyridine, 2-vinyl pyridine, and mixtures thereof; (b) acopolymer consisting of (1) a cationic monomer selected from the groupconsisting of quaternerized products of each of dimethylaminoethylacrylate, dimethylaminoethyl methacrylate, dimethylaminopropylacrylamide, dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof, and (2) an amphoteric monomer selected from the groupconsisting of N-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammoniumbetaine, N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 27. The method of claim 26, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 28. The method of claim 26, wherein said cationic polymer issaid polymer (a).
 29. A method for removing keratotic plugs whichcomprises applying a keratotic plug remover composition onto the skin,and peeling off the composition after the composition is dried, whereinsaid composition comprises a polymer compound having a salt forminggroup, a pigment, an oil component and a solvent,wherein said polymer isone member selected from the group consisting of: (a) a polymerconsisting of a cationic monomer selected from the group consisting ofquaternerized products of each of dimethylaminoethyl acrylate,dimethylaminoethyl methacrylate, dimethylaminopropyl acrylamide,dimethylaminopropyl methacrylamide, dimethylaminostyrene,dimethylaminomethylstyrene, 4-vinyl pyridine, 2-vinyl pyridine, andmixtures thereof; (b) a copolymer consisting of (1) a cationic monomerselected from the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2) an amphoteric monomerselected from the group consisting ofN-(3-sulfopropyl)-N-acryloyloxyethyl-N,N-dimethylammonium betaine,N-(3-sulfopropyl)-N-methacroylamidepropyl-N,N-dimethylammonium betaine,N-(3-carboxymethyl)-N-methacroylamidepropyl-N,N-dimethylammoniumbetaine, and N-carboxymethyl-N-methacroyloxyethyl-N,N-dimethylammoniumbetaine; (c) a copolymer consisting of (1') a cationic monomer selectedfrom the group consisting of quaternerized products of each ofdimethylaminoethyl acrylate, dimethylaminoethyl methacrylate,dimethylaminopropyl acrylamide, dimethylaminopropyl methacrylamide,dimethylaminostyrene, dimethylaminomethylstyrene, 4-vinyl pyridine,2-vinyl pyridine, and mixtures thereof, and (2') a monomer having nosalt forming group selected from the group consisting of vinyl esters ofaliphatic carboxylic acid, (meth)acrylic esters, alkyl vinyl esters,N-vinyl cyclic amides, styrene and alkyl-substituted styrene; and (d)mixtures thereof.
 30. The method of claim 29, wherein said cationicpolymer is a polymer of a cationic monomer selected from the groupconsisting of polymethacryloyloxyethyl trimethylammonium chloride;polymethacrylamidepropyl trimethylammonium chloride; copolymers ofmethacrylamidepropyl trimethylammonium chloride and acrylamidepropyltrimethylammonium chloride; and copolymers of methacrylamidepropyltrimethylammonium chloride and methacryloyloxyethyl trimethylammoniumchloride.
 31. The method of claim 29, wherein said cationic polymer issaid polymer (a).